Mastoid obliteration and external auditory canal reconstruction using 3D printed bioactive glass S53P4 /polycaprolactone scaffold loaded with bone morphogenetic protein-2: A simulation clinical study in rabbits

Fenghui Yu, Xiaoxia Fan,Hongxia Wu,Yangxi Ou, Xuxu Zhao,Tao Chen,Yi Qian,Houyong Kang

Regenerative Therapy（2022）

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摘要

•Canal wall-down mastoidectomy was simulated to construct an animal model.•S53P4/PCL scaffold could reconstruct the normal shape of the external auditory canal.•The scaffold had better antibacterial activity than the same volume of S53P4 powder.•Repair ability of S53P4/PCL scaffolds significantly improved after loading with BMP-2.

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关键词

Mastoid obliteration,External auditory canal Reconstruction, 3D printing,Bioactive glass S53P4

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