Evaluation of pharmacokinetics and safety of a long-term estradiol-releasing stent in rat uterine

Boning Li, Lu Zhang,Yu Xie, Lei Lei,Wenjie Qu,Long Sui

Regenerative Therapy（2022）

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摘要

•The silicone rubber uterine stent continuously released E2 in long term.•The E2-releasing uterine stent revealed more efficient E2 delivery capacity than orally administrated E2.•The E2-releasing uterine stent is safe for endometrium and remote organs.

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关键词

Intrauterine adhesion,17β-estradiol,Silicone rubber,Endometrium regeneration,Uterine stent

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