Diabetes induced by checkpoint inhibition in nonobese diabetic mice can be prevented or reversed by a JAK1 / JAK2 inhibitor

Tingting Ge, Amber‐Lee Phung,Gaurang Jhala,Prerak Trivedi,Nicola Principe,David J De George,Evan G Pappas,Sara Litwak,Laura Sanz‐Villanueva,Tara Catterall,Stacey Fynch,Louis Boon,Thomas W Kay,Jonathan Chee,Balasubramanian Krishnamurthy,Helen E Thomas

Clinical & Translational Immunology（2022）

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摘要

A JAK1/JAK2 inhibitor can prevent and reverse anti-PD-L1-induced diabetes by blocking IFNγ and γc cytokine activities. Our study provides preclinical validation of JAK1/JAK2 inhibitor use in checkpoint inhibitor-induced diabetes.

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关键词

CD8+ T cells,JAK inhibitor,NOD mice,cytokines,immune checkpoint inhibitor‐induced diabetes

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