PD-L1 evaluation in the gastrointestinal tract: from biological rationale to its clinical application.

Luca Mastracci,Federica Grillo,Paola Parente,Irene Gullo,Michela Campora,Valentina Angerilli,Chiara Rossi,Maria Luisa Sacramento,Gianmaria Pennelli,Alessandro Vanoli,Matteo Fassan

Pathologica（2022）

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摘要

In this Review, we describe the technical aspects and challenges related to PD-L1 immunohistochemical assays, the current role of PD-L1 as a biomarker in clinical practice and we outline the main studies and clinical trials analyzing the prognostic and predictive value of PD-L1 in gastrointestinal cancers.

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关键词

PD-L1,clinical trials,gastrointestinal neoplasms,immunohistochemistry,immunotherapy

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