Regulatory Effect of JAK2/STAT3 on the Immune Function of Endotoxin-tolerant Dendritic Cells and its Involvement in Acute Liver Failure.

Yukai Chen,Chaochen Hou,Naibin Yang,Yanyan Yang,Youran Chen,Deyong Kong,Yuchun Jiang,Minghao Lin,Sijie Zheng,Shanshan Li,Mingqin Lu

Journal of clinical and translational hepatology（2022）

引用 3|浏览16

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摘要

The gene had an important role in induction of endotoxin tolerance. SOCS1ETDCs alleviated lipopolysaccharide/D-galactosamine-induced ALF by downregulating the JAK2/STAT3 signaling pathway.

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关键词

Acute,Dendritic cells,Endotoxin tolerance,Janus kinase 2/signal transducers and activators of transcription 3 (JAK2/STAT3),Liver failure

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