Sensitizing brain metastases to stereotactic radiosurgery using hyperbaric oxygen: A proof-of-principle study

Alan C. Hartford,Gobind S. Gill,Divya Ravi,Tor D. Tosteson,Zhongze Li,Gregory Russo,Clifford J. Eskey,Lesley A. Jarvis,Nathan E. Simmons,Linton T. Evans,Benjamin B. Williams,David J. Gladstone,David W. Roberts,Jay C. Buckey

Radiotherapy and Oncology（2022）

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摘要

•HBO may be successfully administered within 15 minutes prior to SRS delivery.•HBO combined with SRS for brain metastases showed no excess toxicity.•Clinical outcomes trended favorably for HBO with SRS (but not significant).•Phase II trial of pre-op SRS will study cellular & clinical effects of adding HBO.

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关键词

Hyperbaric oxygen,Brain metastases,Stereotactic radiosurgery,Radiation sensitizer

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