Discovery of I-0436650, a potent and selective SHP2 allosteric inhibitor for the treatment of RAS driven solid tumors

F. Puca,V. Fodale, P. Randazzo, D. Fabbrini, A. Missineo, M. Bisbocci,S. Esposito, M. Nibbio, J. Amaudrut, F. Colaceci, R. Sasso, F. Scalabrì, S. Loponte, C. Alli,V. Pucci,C. Montalbetti, R. Di Fabio, A. Petrocchi, A. Carugo, C. Toniatti

European Journal of Cancer(2022)

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selective shp2 allosteric inhibitor,solid tumors
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