Therapeutic potential of plant iridoids in depression: a review.

Pharmaceutical biology(2022)

引用 4|浏览23
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摘要
Iridoids exert antidepressant effects by elevating monoamine neurotransmitters, reducing pro-inflammatory factors, inhibiting hypothalamic-pituitary-adrenal (HPA) axis hyperactivity, increasing brain-derived neurotrophic factor (BDNF) and its receptors, and elevating intestinal microbial abundance. Further detailed studies on the pharmacokinetics, bioavailability, and key molecular targets of iridoids are also required in future research, ultimately to provide improvements to current antidepressant medications.
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关键词
Secoiridoids,mental disorders,molecular mechanisms
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