Does a Single Exposure to General Anesthesia Have a Cumulative Effect on the Developing Brain after Mild Perinatal Asphyxia?

Sebastian Isac,Bogdan Pavel,Maria Dobre,Elena Milanesi,Irina-Mihaela Matache, Raul-Mihai Paun,Artsiom Klimko,Mara Ioana Iesanu,Gabriela Droc,Ana-Maria Zagrean

Life (Basel, Switzerland)（2022）

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摘要

Both PA and GA contribute to glial activation, however with no cumulative effect. Moreover, PA reduces the rats' mobility, irrespective of GA exposure, while memory evaluated by the novel object recognition test was not influenced.

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关键词

behavioral impairments,general anesthesia,glial activation,hippocampus,neuroinflammation,perinatal asphyxia

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