Hydrogen Sulfide and Its Donors: Keys to Unlock the Chains of Nonalcoholic Fatty Liver Disease.

Hydrogen sulfide (HS) has emerged as the third "gasotransmitters" and has a crucial function in the diversity of physiological functions in mammals. In particular, HS is considered indispensable in preventing the development of liver inflammation in the case of excessive caloric ingestion. Note that the concentration of endogenous HS was usually low, making it difficult to discern the precise biological functions. Therefore, exogenous delivery of HS is conducive to probe the physiological and pathological roles of this gas in cellular and animal studies. In this review, the production and metabolic pathways of HS in vivo, the types of donors currently used for HS release, and study evidence of HS improvement effects on nonalcoholic fatty liver disease are systematically introduced.