The Legacy of Parental Obesity: Mechanisms of Non-Genetic Transmission and Reversibility

Gemma Comas-Armangue, Lela Makharadze, Melisa Gomez-Velazquez,Raffaele Teperino


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While a dramatic increase in obesity and related comorbidities is being witnessed, the underlying mechanisms of their spread remain unresolved. Epigenetic and other non-genetic mechanisms tend to be prominent candidates involved in the establishment and transmission of obesity and associated metabolic disorders to offspring. Here, we review recent findings addressing those candidates, in the context of maternal and paternal influences, and discuss the effectiveness of preventive measures.
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Key words
obesity, HFD, epigenetics, DOHaD, POHaD, non-genetic inheritance, intergenerational inheritance, reversibility
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