Early-Stage Contactin-Associated Protein-like 2 Limbic Encephalitis: Clues for Diagnosis.

Jeanne Benoit,Sergio Muñiz-Castrillo,Alberto Vogrig,Antonio Farina,Anne-Laurie Pinto,Geraldine Picard,Veronique Rogemond,Deborah Guery,Agusti Alentorn,Dimitri Psimaras,Sylvain Rheims,Jérôme Honnorat,Bastien Joubert

Neurology(R) neuroimmunology & neuroinflammation（2023）

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摘要

CASPR2-encephalitis has a progressive course and is highly heterogeneous at the early stage. In men older than 50 years, otherwise unexplained seizures, cerebellar ataxia, and/or neuropathic pain are suggestive of early-stage CASPR2-encephalitis, especially if they coincide with recent asthenia, mood disorders, or insomnia.

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