Influence of genetic polymorphisms on mechanical pain sensitivity and endogenous pain modulation of trigeminal and spinal areas.

Flávia Fonseca Carvalho Soares,Dyna Mara Araújo Oliveira Ferreira, Amanda Ayla Raimundini,Thiago José Dionísio,Carlos Ferreira Dos Santos,Paulo César Rodrigues Conti,Yuri Martins Costa,Leonardo Rigoldi Bonjardim

Journal of oral rehabilitation（2023）

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摘要

Genetic polymorphisms had a slight contribution to endogenous pain modulation as indicated by the significant association with WUR but did not contribute to mechanical pain sensitivity. On the other hand, the presence of painful TMD and the sleep quality contributed significantly to mechanical pain sensitivity.

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endogenous pain modulation,genetic polymorphism,pain sensitivity,quantitative sensory testing,temporomandibular disorder

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