DNAM1 and TIGIT balance the T cell response, with low T cell TIGIT expression corresponding to inflammation in psoriatic disease.

Marleen E Jacobs,Juliëtte N Pouw,Michel A Olde Nordkamp,Timothy R D J Radstake,Emmerik F A Leijten,Marianne Boes

Immunotherapy advances（2021）

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摘要

CD155 is increased on pro-inflammatory APCs, while the receptors DNAM1 and TIGIT expressed on T cells balance the inflammatory response by T cells. In psoriatic disease, low TIGIT expression on T cells is associated with systemic inflammation.

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关键词

CD155,DNAM1,TIGIT,inflammation,psoriatic disease

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