Asiaticoside Prevents Oxidative Stress and Apoptosis in Endothelial Cells by Activating ROS-dependent p53/Bcl-2/Caspase-3 Signaling Pathway.

Zhenwen Liang,Yu Chen,Rifang Gu,Qi Guo,Xuqiang Nie

Current molecular medicine（2022）

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摘要

AC alleviates t-BHP-induced oxidative injury and apoptosis in HUVECs through the ROS-dependent p53/Bcl-2/Caspase-3 signaling pathway. It may be a potential antioxidant applied in metabolic disorders and pharmaceutical products.

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关键词

Asiaticoside,Human umbilical vein endothelial cells,Oxidative stress,Reactive oxygen species,Tert-butyl hydrogen peroxide,p53 signaling pathway

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