Systematic comparison with autoimmune liver disease identifies specific histological features of immune checkpoint inhibitor-related adverse events.

Alexander Coukos,Julien Vionnet,Michel Obeid,Hasna Bouchaab,Solange Peters,Sofiya Latifyan,Alexandre Wicky,Olivier Michielin,Haithem Chtioui,Darius Moradpour,François Fasquelle,Christine Sempoux,Montserrat Fraga

Journal for immunotherapy of cancer（2022）

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摘要

Liver irAEs have broad clinical, laboratory and histological presentations. Histological features of irAEs and AILD are distinct, likely underpinning their different immunological mechanisms.

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关键词

CTLA-4 antigen,autoimmunity,cytotoxicity, immunologic,immunotherapy,programmed cell death 1 receptor

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