Impact of the combination of sintilimab and chemotherapy on the tumor and paratumor PD‐L1 , IDO , TIM ‐3, FOXP3 + and CD8 expressions in patients with advanced esophageal squamous cell carcinoma

Shifa Zhang,Haibo Cai, Junjun Huang,Gongchao Wang

Thoracic Cancer（2022）

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摘要

This study provides new insight into the effects of CI treatment on isolated CD8+ T cell infiltration, PD-L1, IDO, FOXP3+ and TIM-3 expression as well as their cross-talk in different tissues enabling a better understanding of the impact of CI treatment on the immune microenvironment.

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关键词

IDO,PD-1 inhibitors,PD-L1,TIM-3,esophageal cancer,immunotherapy

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