SOX2 Modulates the Nuclear Organization and Transcriptional Activity of the Glucocorticoid Receptor

Martin Stortz,Camila Oses,Camila Vázquez Echegaray,Adali Pecci,Alejandra Guberman,Diego M. Presman,Valeria Levi

Journal of Molecular Biology（2022）

引用 4|浏览12

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摘要

•This is the first study addressing the crosstalk between GR and SOX2.•SOX2 impairs the formation of GR intranuclear condensates.•SOX2 modulates GR’s ability to bind DNA and control gene expression.•SOX2-GR crosstalk may involve GR’s coactivator NCoA-2.•SOX2-GR crosstalk could be relevant in many types of cancer.

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关键词

condensates,pluripotency transcription factors,steroid receptors,phase separation,coactivators

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