Effect of autologous platelet-rich plasma treatment on refractory thin endometrium during the frozen-embryo transfer cycle: a single arm self-controlled trial in 100 patients

Platelet-rich plasma (PRP), as cutting-edge technology, is widely applied in regenerative medicine, including cartilage repair, alopecia, and management of diabetic foot ulcers. Patients with refractory thin endometrium, defined as less than 7mm of the endometrial thickness (EMT) unresponsive to standard treatment options, were associated with reduced incidence of pregnancy rate and often resulted in cycle cancellation. PRP emerged as a new therapeutic option to improve implantation rate and pregnancy outcome. The aim of this study is to identify the effect of intrauterine autologous PRP infusion on implantation and pregnancy in patients with refractory thin endometrium.