Evaluation of Molecular Properties versus In Vivo Performance of Aflibercept, Brolucizumab, and Ranibizumab in a Retinal Vascular Hyperpermeability Model.

William Schubert,Carsten Terjung,Ashique Rafique,Carmelo Romano,Philipp Ellinger,Kay D Rittenhouse

Translational vision science & technology（2022）

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摘要

In silico, in vitro, and in vivo integrated studies provide information that enables the enhanced characterization of translational properties of anti-VEGF agents currently used for the treatment of retinal diseases.

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关键词

retinal vascular hyperpermeability model,aflibercept,ranibizumab

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