Decreased total motile sperm count is not associated with increased frequency of segmental aneuploidies

Preimplantation genetic testing for aneuploidy (PGT-A) results can report segmental aneuploidies in the human embryo. It has been shown that segmental aneuploidies can be associated with parent-of-origin. Specifically, the paternal allele can be affected in up to 2/3 of complex segmental imbalances (which are characterized by the presence of two or more aberrations on the same chromosome). There are currently no studies investigating the link between abnormal semen parameters such as total motile count (TMC) and segmental aneuploidies. This study aims to assess the association between concentration of TMC and the frequency in segmental aneuploidies.