Effect of Dapagliflozin on Cardiac Function and Metabolic and Hormonal Responses to Exercise.

Roselle A Herring,Iain Parsons,Fariba Shojaee-Moradie,Mary Stevenage,Nicola Jackson,Ralph Manders,A Margot Umpleby,Barbara A Fielding,Melanie Davies,David L Russell-Jones

The Journal of clinical endocrinology and metabolism（2023）

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摘要

During exercise, GH may be more important than catecholamines in driving the shift from glucose to fatty acid metabolism by SGLT2 inhibitors. The 4-week crossover design showed changes in cardiac function were rapid in onset and reversible.

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关键词

SGLT2 inhibitor,cardiac function,exercise echocardiogram,growth hormone,ketones

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