Methylation microarray-based detection of clinical copy-number aberrations in CLL benchmarked to standard FISH analysis

Dianna Hussmann,Anna Starnawska,Louise Kristensen,Iben Daugaard,Oriane Cédile, Vivi Quoc Nguyen,Tina E Kjeldsen,Christine Søholm Hansen,Jonas Bybjerg-Grauholm,Thomas Kristensen,Thomas Stauffer Larsen,Michael Boe Møller,Charlotte Guldborg Nyvold,Lise Lotte Hansen,Tomasz K Wojdacz

Genomics（2022）

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摘要

Copy-number aberrations (CNAs) are assessed using FISH analysis in diagnostics of chronic lymphocytic leukemia (CLL), but CNAs can also be extrapolated from Illumina BeadChips developed for genome-wide methylation microarray screening. Increasing numbers of microarray data-sets are available from diagnostic samples, making it useful to assess the potential in CNA diagnostics.

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关键词

Copy-number aberration,CNA assessment,Methylation microarray,EPIC,450k,Chronic lymphocytic leukemia

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