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Scaffold Hopping Via Ring Opening Enables Identification of Acyclic Compounds As New Complement Factor D Inhibitors.

Weihe Zhang,Minwan Wu,Satish Vadlakonda,Luis Juarez,Xiaogang Cheng,Saritha Muppa,Venkat Chintareddy,Lakshminarayana Vogeti,Debra Kellogg-Yelder, Jason Williams,Kevin Polach,Xilin Chen,Krishnan Raman,Y. S. Babu,Pravin Kotian

Bioorganic & Medicinal Chemistry（2022）

Cited 4|Views19
Key words
Complement Factor D,Complement Factor D inhibitor,CFD inhibitor,Factor D inhibitor,Structure-guided drug design,Scaffold hopping
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