Humoral efficacy of the third SARS-CoV-2 vaccine dose in Multiple Sclerosis subjects undergoing different disease-modifying therapies

Giorgia Teresa Maniscalco,Antonietta Liotti,Anne Lise Ferrara,Elio Prestipino,Simona Salvatore,Maria Elena Di Battista,Ornella Moreggia,Daniele Di Giulio Cesare, Roberta Vastano,Martina Belardo,Massimo Napolitano,Angelo Ranieri, Katia Longo,Vincenzo Andreone,Veronica De Rosa

Multiple Sclerosis and Related Disorders（2022）

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摘要

•DMTs affect the SARS-CoV-2 humoral response to the booster dose in pwMS.•Humoral response in IFN-, DMF- and TERI-treated pwMS is comparable to HS.•The booster dose enhances SARS-CoV-2 specific immunity in low-responders pwMS.

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关键词

Severe acute respiratory syndrome coronavirus (SARS-CoV)-2,Coronavirus disease 2019 (COVID-19),BNT162b2 booster vaccine,Disease modifying therapies,Multiple sclerosis,Humoral response

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