Interplay between long non-coding RNA MALAT1 and pyroptosis in diabetic nephropathy patients

Heba M Shoeib,Walaa A Keshk,Ghada M Al-Ghazaly,Ayman A Wagih,Samia A El-Dardiry

Gene（2023）

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摘要

•Impaired redox status and inflammatory burden play important roles in DN development.•MALAT1 expression and pyroptosis were significantly induced in early DN.•MALAT1 expression, caspase 1 level and interleukin 18 level could be used as biomarkers for early detection of DN.

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关键词

Diabetic nephropathy (DN),Diabetes mellitus (DM),Metastasis-associated lung adenocarcinoma transcript 1(MALAT1),urinary albumin-creatinine (UACR),Interleukin 18 (IL18),Receiver operating characteristic (ROC)

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