Lipopolysaccharide-induced changes in effort-related motivational function: Interactions with 2-deoxyglucose

•The effects of lipopolysaccharide (LPS) on effort-based choice were assessed in rats.•LPS reduced lever pressing for preferred food pellets but did not affect chow intake.•LPS reduced intake of the preferred food pellets in free feeding preference tests.•2-DG, which blocks glycolysis, significantly reversed lever pressing effects of LPS.•The dopamine transport inhibitor methylphenidate did not alter LPS effects.