Development and characterization of patient-derived salivary gland cancer organoid cultures

Gerben Lassche,Wim van Boxtel,Tilly W Aalders,Onno van Hooij,Adriana C H van Engen-van Grunsven,Gerald W Verhaegh,Carla M L van Herpen,Jack A Schalken

Oral Oncology（2022）

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摘要

•Short-term patient-derived organoids of salivary gland cancers could be established.•This included adenoid cystic carcinoma, salivary duct carcinoma and mucoepidermoid carcinoma.•Phenotypic and genotypic mimicry of organoids to parental tissue was observed.•Small-scale drug screens using established organoids were feasible.

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关键词

Organoids,Salivary gland neoplasms,Adenoid Cystic Carcinoma,Salivary Duct Carcinoma,Precision medicine

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