Extract of Ginkgo biloba leaves attenuates neurotoxic damages in rats and SH-SY5Y cells exposed to a high level of fluoride

Jie Xiang,Yan-Lin Ma,Jian Zou,Xiao-Xiao Zeng,Xiao Xiao,Yan-Long Yu,Yang-Ting Dong,Long-Yan Ran,Xiao-Lan Qi,Wei Hong,Yan-Hui Gao,Zhi-Zhong Guan

Journal of Trace Elements in Medicine and Biology（2023）

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摘要

•Chronic fluorosis decreased learning and memory of rats and induced neurotoxicity.•Ginkgo biloba attenuates the impairment of brain and the neurotoxicity in rats with chronic fluorosis and SH-SY5Y cells exposed to fluoride.•The underlying mechanism in that the Ginkgo biloba extract attenuated neurotoxic damage induced by fluorosis may involve inhibition of PARP-1 activity and promotion of the expression of SIRT1.

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关键词

Fluoride,Ginkgo biloba extract,Neurotoxicity,Rats,SH-SY5Y cells

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