Dual Role of Inositol-requiring Enzyme 1α–X-box Binding protein 1 Signaling in Neurodegenerative Diseases

Cailin Wang,Yanmin Chang,Jiahui Zhu,Rong Ma,Gang Li

Neuroscience（2022）

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摘要

•IRE1α–XBP1 signaling functions in brain physiology.•Crosstalk between IRE1α–XBP1 signaling and other signaling is context specific.•Dual role of IRE1α–XBP1 signaling within and among neurodegenerative diseases.•Possible pharmacological targets of the IRE1α–XBP1 axis.

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关键词

Unfolded protein response,IRE1α,XBP1,Neurodegeneration,Autophagy,Neuroinflammation,Calcium

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