Gabapentin to treat acute alcohol withdrawal in hospitalized patients: A systematic review and meta-analysis

•Treatment with gabapentin may benefit alcohol withdrawal inpatients based on its use in Alcohol Use Disorder outpatients and mechanism of action.•Benzodiazepines are commonly used to treat hospitalized alcohol withdrawal syndrome patients, but are associated with several adverse drug events.•Current studies examining the inpatient treatment of alcohol withdrawal with gabapentin versus benzodiazepines are low-quality with design flaws.•Randomized, controlled studies of gabapentin to treat hospitalized patients suffering alcohol withdrawal syndrome are required.