A Preliminary Study of Frequency and Clinical Relevance of Cytotoxic Peripheral CD4 and CD8 T Cells in Patients with Anti-MDA5 Positive Dermatomyositis.

Fengyun Jia,Shan Jiang,Jiamin Zhang,Qiong Fu,Xiaoming Zhang,Yan Ye

Rheumatology and immunology research（2022）

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摘要

Substantial changes of cytotoxic T cell subsets are observed in active MDA5DM patients. In addition, a high frequency of GZMKGZMB CD4 and CD8 T cells is associated with unfavorable prognosis in MDA5DM. More studies are warranted to further explore the roles of cytotoxic T cells in MDA5DM.

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关键词

anti-melanoma differentiation-associated gene 5-positive dermatomyositis,cytotoxic T cells,granzyme,prognosis

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