The proportion of memory CD8+T cell predict infection event in patients with peritoneal dialysis

Introduction: The immune senescence marked by inflation of memory T cell is established in end-stage renal disease (ESRD) patients with peritoneal dialysis(PD). These patients suffer high incidence of infectious disease, which has been relevant to immune dysfunction. However the association of immune senescence with infection in PD patients is not clear. This prospective study is aim to investigate relationship between proportion of T cell subsets and infection event in patients on PD. Methods: We enrolled patients on PD> 6 months from January 1,2016 to December 30,2016 and followed until April 30,2020. Baseline T cell subsets from blood were collected at the time of recruitment. The primary end point was infection event including peritonitis, exit site infection, pneumonia, urinary tract infection and other infection. Results: There were 94 patients (46 male) with a mean age of 56.1 +/- 14.9 years old enrolled during follow-up period, and 26 patients suffered infection events. Higher proportion of effector memory(EM) CD8+ T cell was found in patients with infection than those without infection. There was no difference of distribution of EM CD8+ T cell between PD-related and non-dialysis infection. Increased level of EM CD8+ T cell was risk factor for first infection event in PD patients. Conclusion: High level of EM CD8+ T cell could be a significant predictor of infection event in patients on PD.