Network pharmacology, molecular docking technology integrated with pharmacodynamic study to explore the potential targets and mechanism of Xinkeshu tablets against myocardial ischemia reperfusion injury

•The pharmacodynamics of XKST on MIRI rat model was studied.•Network pharmacology was utilized to determine the mechanism and targets of XKST.•DEGs analysis based on GEO database was used to further identify core targets.•Molecular docking study was approved for core targets and quality markers of XKST.