Islet Autoantibody Level Distribution in Type 1 Diabetes and Their Association With Genetic and Clinical Characteristics.

Sian Louise Grace,Jack Bowden,Helen C Walkey,Akaal Kaur,Shivani Misra,Beverley M Shields,Trevelyan J McKinley,Nick S Oliver, Timothy J McDonald,Desmond G Johnston,Angus G Jones,Kashyap A Patel

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM（2022）

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摘要

Islet autoantibody levels provide additional information over positivity in T1D at diagnosis. Bimodality of GADA and IA-2A autoantibody levels highlights the novel aspect of heterogeneity of T1D. This may have implications for T1D prediction, treatment, and pathogenesis.

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关键词

glutamate decarboxylase autoantibodies (GADA),islet antigen-2 autoantibodies (IA-2A) and zinc transporter 8 autoantibodies (ZnT8A),type 1 diabetes

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