A straightforward synthesis of potentially biologically active novel urea derivatives from 1,2,3,4-tetrahydronaphthalene-2-carboxylic acids

Potentially biologically active urea derivatives have been prepared in an efficient one-pot procedure from 1,2,3,4-tetrahydronaphthalene-2-carboxylic acids and characterized via several spectroscopy techniques. Ideal reaction times and temperatures, as well as the absence of metal catalysts and time-consuming and expensive purification chromatographic conditions, allowed the products to be in good yield. The obtained unsymmetrical urea derivatives in an economical and efficient synthetic methodology would be of great interest to be used for potential applications related to drug design, pharmaceutical, and medicinal chemistry. Graphical abstract