N-myc-Mediated Translation Control Is a Therapeutic Vulnerability in Medulloblastoma.

Duygu Kuzuoglu-Ozturk,Ozlem Aksoy,Christin Schmidt,Robin Lea,Jon D Larson,Ryan R L Phelps,Nicole Nasholm,Megan Holt,Adrian Contreras,Miller Huang,Shannon Wong-Michalak,Hao Shao,Robert Wechsler-Reya,Joanna J Phillips,Jason E Gestwicki,Davide Ruggero,William A Weiss

Cancer research（2023）

引用 3|浏览25

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摘要

Translatome analysis in medulloblastoma shows that N-myc drives selective translation of transcripts that promote protein homeostasis and that represent new therapeutic vulnerabilities.

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关键词

medulloblastoma,translation control,n-myc

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