Differences in Inflammatory Pathways Between Dutch South Asians vs Dutch Europids With Type 2 Diabetes.

Maaike E Straat,Borja Martinez-Tellez,Huub J van Eyk,Maurice B Bizino,Suzanne van Veen,Eleonora Vianello,Rinke Stienstra,Tom H M Ottenhoff,Hildo J Lamb,Johannes W A Smit,Ingrid M Jazet,Patrick C N Rensen,Mariëtte R Boon

The Journal of clinical endocrinology and metabolism（2023）

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摘要

South Asian patients with T2D show a more activated IFN-signaling pathway compared to Europid patients with T2D, which is more pronounced in women than men. We speculate that a more activated IFN-signaling pathway may contribute to the more rapid progression of T2D in South Asian compared with Europid individuals.

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关键词

B lymphocytes,ethnicity,gene expression,interferon gamma,metabolic syndrome

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