Sphingosine Kinase 1 Acts as a Hypoxia-Upregulated Oncogene to Regulate Cell Invasion and Resistance to NK Cell Killing in Bladder Carcinoma Cells.

Annals of clinical and laboratory science(2022)

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摘要
Targeting SphK1 may inhibit hypoxia-evoked invasion and immune evasion via the S1P/HIF-1α signaling, indicating a promising therapeutic target for BC.
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关键词
Bladder cancer,NK cell killing,SphK1/S1P,cell invasion,hypoxia
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