GENLIB: New Function to Simulate Haplotype Transmission in Large Complex Genealogies

AbstractSummaryFounder populations with deep genealogical data are well suited for investigating genetic variants contributing to diseases. Here, we present a new function added to the genealogical analysis R package GENLIB, which can simulate the transmission of haplotypes from founders to probands along very large and complex user-specified genealogies.Availability and implementationThe new function is available in the latest version of the GENLIB package (v1.1.6), available on the CRAN repository and fromhttps://github.com/R-GENLIB/GENLIB. Stand-alone scripts for analyzing the output of the function can be accessed athttps://github.com/R-GENLIB/simuhaplo_scripts.