Assisted reproductive technology causes reduced expression of amino acid transporters in human full-term placentas

Pathology - Research and Practice(2022)

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摘要
ART leads to the expressions of amino acid transporter genes SNAT1, SNAT2, SNAT4 and LAT2 significantly down-regulated in placenta accompanied by the PI3K-AKT-mTOR signaling inhibition, which suggests that ART may affect the function of placenta amino acid transporter during the late pregnancy, leading to enlarged placentas and probably low birth weight.
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关键词
Assisted reproductive technology (ART),Placenta,Amino acid transporter,PI3K-AKT-mTOR
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