IGFBP3 inhibits tumor growth and invasion of lung cancer cells and is associated with improved survival in lung cancer patients

Hartmut Kuhn,Armin Frille, Marie Anna Petersen,Jonas Oberhuber-Kurth, Lukas Hofmann, Albrecht Gläser,Sabine Taubenheim,Sabine Klagges,Sebastian Kraemer,Johannes Broschewitz,Maximilian von Laffert,Hubert Wirtz

Translational Oncology（2023）

引用 4|浏览6

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摘要

•IGFBP3 inhibits lung cancer cell spheroid growth (3D proliferation).•IGFBP3 inhibits invasion by reduction of MMP activity.•Higher IGFBP3 plasma levels correlates with a less aggressive tumor.•Increased plasma levels is associated with improved overall cancer patient survival.

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lung cancer cells,lung cancer,tumor growth

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