First Diagnosis of Immunoglobulin A Nephropathy Following SARS-CoV-2 mRNA Vaccination in Japan

Shinya Yokote,Hiroyuki Ueda,Akihiro Shimizu,Masahiro Okabe,Kotaro Haruhara,Takaya Sasaki,Ryousuke Aoki,Kensuke Joh,Harumi Saeki,Shigeki Tomita,Nobuo Tsuboi,Hitoshi Suzuki,Yusuke Suzuki,Takashi Yokoo

Kidney international reports（2023）

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摘要

The SARS-CoV-2 mRNA vaccine has been effective against COVID-19.1,2 However, following mass-scale SARS-CoV-2 mRNA vaccination, several immune-mediated disorders, including newly diag-nosed or exacerbated cases of IgA nephropathy (IgAN), have been reported worldwide.3-6Majority of the reported IgAN cases associated with SARS-CoV-2 mRNA vaccination show gross hematuria; however, the commonality in the kidney histopathological find-ings remains uncharacterized. In this study, patients first diagnosed with IgAN by kidney biopsy due to gross hematuria following SARS-CoV-2 mRNA vaccina-tion at 6 medical centers were evaluated. The details of study methods are shown in the Supplementary Methods.S1-S4

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关键词

gloss hematuria,IgA nephropathy,kidney biopsy,Oxford classification,SARS-CoV-2,vaccination

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