Alignment prior to total knee arthroplasty in high tibial osteotomy patients has no effect on subsequent functional outcomes

Introduction The influence of prior high tibial osteotomy (HTO) on total knee arthroplasty (TKA) functional outcomes remains widely debated. Alignment of failed HTO can pose technical challenges with subsequent TKA. The primary aim of this study was to evaluate the influence of HTO alignment on the clinical outcomes of subsequent TKA. The secondary aim was to compare the time to TKA for each HTO alignment type. Methods Patients who underwent TKA post lateral closing-wedge HTO for symptomatic medial compartment osteoarthritis between 2001 and 2014 were prospectively followed up for 2 years. A total of 159 patients were assigned to three groups based on their pre-TKA femora tibia angles using long lower limb radiographs: varus alignment (VrA) <= 3(o) valgus, neutral alignment (NA) 3-9(o) valgus alignment, valgus alignment (VlA) >= 9(o) valgus. Functional outcomes were quantified using Knee Society Function Score and Knee Scores (KSFS and KSKS respectively), modified Oxford Knee Score (OKS), Short Form 36 Physical Component Score (SF-36 PCS), and SF-36 Mental Component Score (SF-36 MCS). Pre-operative and post-operative knee range of motion were also measured. Results Mean pre-TKA KSKS in VrA patients (35 +/- 18) was significantly lower than both NA (51 +/- 19) and VlA (40 +/- 21) patients (p < .05). Otherwise, there was no significant difference in functional outcome scores (KSFS, KSKS, OKS, SF-36 PCS and SF-36 MCS) or range of motion at 6 months and 2 years post-TKA. The mean duration from HTO to TKA was 12 +/- 7 years with no significant differences between VrA, NA, and VlA HTO to TKA (13 +/- 7 years, 13 +/- 6 years and12 +/- 8 years respectively, p > .05). Conclusion HTO alignment did not influence time to subsequent TKA. HTO alignment did not influence early outcomes as well as radiological outcomes of subsequent TKA.