Study on chronic toxicity of rhubarb extract in Sprague-Dawley rats.

Wenxiang Yang,Ji Liu,Yanhua Zheng,Jingjing Qu,Xiaoqiao Tang,Hong Bai,Chunxia Liu,Bolin Fan

Heliyon（2022）

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摘要

The NOAEL of rhubarb extract on chronic toxicity (52 weeks) of Sprague-Dawley rats was 101 mg/kg in female and 94 mg/kg in male, and the LOAEL was 408 mg/kg in female and 381 mg/kg in male. The target organ of toxicity was the kidney, and the target cells was tubular epithelial cells.

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Chronic toxicity,Rhubarb extract,Sprague-Dawley rats

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