Anti- Acinetobacter baumannii single-chain variable fragments show direct bactericidal activity.

Eilnaz Basardeh, Somayeh Piri-Gavgani,Behnoush Soltanmohammadi,Mostafa Ghanei,Mir Davood Omrani,Mahdieh Soezi,Mohammad Ali Shokrgozar,Masoumeh Azizi,Abolfazl Fateh,Farzam Vaziri,Seyed Davar Siadat,Zahra Sharifzadeh,Fatemeh Rahimi-Jamnani

Iranian journal of basic medical sciences（2022）

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摘要

These results suggest that combining last-resort antibiotics with bactericidal scFvs could provide promising outcomes in immunocompromised individuals with infections.

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关键词

Acinetobacter baumannii,Antibacterial agents,Colistin,Monoclonal antibody,Phage display library,Single-chain variable-fragment

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