Inhibition of BRD4 decreases fibrous scarring after ischemic stroke in rats by inhibiting the phosphorylation of Smad2/3

Xuemei Li,Huimin Zhu, Jun Wen,Jiagui Huang,Yue Chen,Mingfen Tian,Jiangxia Ren,Li Zhou,Qin Yang

Brain Research（2022）

引用 3|浏览6

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摘要

•TGF-β1 and MCAO/R injury upregulated BRD4 expression in vitro and in vivo.•Inhibition of BRD4 decreased TGF-β1-induced meningeal fibroblast activation.•BRD4 knockdown inhibited fibrous scarring and improved neurological function.•Inhibition of BRD4 decreased the phosphorylation of Smad2/3 in vitro and in vivo.

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关键词

CNS,BRD4,TGF-β1,SD,MCAO/R,mNSS,SY,BET,α-SMA,COL1,FN,FBS,CCK-8,ADV-shBRD4,ADV-Ctrl,DMSO,ANOVA,NF-κB,Nrf-2/HO-1

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