Association Between Single Nucleotide Polymorphisms of miRNAs and Gastric Cancer: A Scoping Review

Background: Gastric cancer (GC) is the third leading cause of cancer-related mortality worldwide, and single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) are believed to affect the occurrence and progression of cancer by altering the expression and biological functions of miRNAs.Methods: The present scoping review aimed to discuss microRNAs SNPs (miR-SNPs) that were found to be associated with GC in the following two contexts: (1) the biological effects on GC based on SNP localization and (2) the associations between miRNA-SNPs and clinical factors (susceptibility, tumor size, metastasis, overall survival, and prognosis) of GC.Results and Conclusions: Information on miRNAs was collected, including the mutation site, proven target genes, and the possible impact on GC. We speculate that the SNPs of miRNAs (miR-499, miR-146a, miR-149, miR-148, miR-27a, miR-608, miR-196a-2) play a key role in GC, and the findings of this study may provide better insights into the versatile role of SNPs in GC.