Genetic screening and analysis of TUBB8 variants in females seeking ART

Tingting Lin,Weiwei Liu,Wei Han,Keya Tong,Yezhou Xiang,Haiyuan Liao,Ke Chen,Yao He,Dongyun Liu,Guoning Huang

Reproductive BioMedicine Online（2023）

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摘要

Research question: More than 100 variants have been identified in the TUBB8 gene, which account for approximately 30% of infertile women with oocyte maturation defects. But what is the correlation between the highly phenotypic diversity and genetic variability? Are there other variants in TUBB8 related to female infertility?

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关键词

Genetic counselling,Oocyte maturation defect,Primary female infertility,TUBB8 gene

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