Phenotypic Profile of Mycobacterium tuberculosis -Specific CD4 T-Cell Responses in People With Advanced Human Immunodeficiency Virus Who Develop Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome.

Open forum infectious diseases(2023)

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摘要
Although the murine model of complex-IRIS suggests that EomesCD4 T cells underly IRIS, TB-IRIS was not associated with Eomes expression in patients. -specific IFNγCD4 T-cell responses in TB-IRIS patients are differentiated, highly activated, and potentially cytotoxic.
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关键词
HIV-1/TB coinfection,Tbet/Eomes,Th-1 responses,immune activation,paradoxical TB-IRIS
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